Contraindications and Indications of Domperidone

Specific Indications

Gastroparesis

It is a clinical disorder representing delayed stomach emptying even in the absence of any possible mechanical obstruction in the gastric outlet. The gastroparesis is usually idiopathic, or might occur due to some complications in abdominal surgery or a diabetic complication. This disorder induces abdominal bloating and pain, early satiety, fullness after eating, vomiting, nausea, etc. The domperidone is particularly useful in idiopathic as well as diabetic gastroparesis.

Parkinson’s disease

It is considered as a chronic neurological disorder characterized by a decreased amount or activity in the brain, which ultimately leads to severe illness conditions, such as stiffness of movement, tremor, rigidity, and related signs and symptoms. The poor functions of gastrointestinal region resulting in vomiting and nausea are considered as a serious concern for the patients with Parkinson’s disease or Parkinson like diseases which are characterized by tremors, since most of the medication in such conditions or disorders are given by mouth. Therefore, in case of vomiting, the administered drug expels out resulting in missing of dose regime. Therefore, this drug is particularly useful in relieving Parkinson’s disease associated gastrointestinal symptoms, irrespective of its property of blocking dopamine receptors (that may probably worsen the conditions of Parkinson’s disease), since it could not pass through blood brain barrier. Moreover, the domperidone also improves and increases the bio availability of levodopa which is mainly used to treat Parkinson’s disease.

Functional dyspepsia

Domperidone is also useful in the management of functional dyspepsia in almost all age groups, including adults as well as children.

Pediatric reflux

It is also considered as a significant line of treatment in minimizing the symptoms of paediatric reflux. However, it is it is also thought be an extremely powerful drug to be used in infants and babies. It is also recommended that the children and adults weighing under or less than 35kg should be carefully monitored while administering this drug.

Symptomatic Treatment

It is also indicated in the symptomatic treatment of “dyspeptic symptom complex” which might be associated with postponed gastric emptying with unusual epigastric feelings of swelling, abdominal distension, epigastric discomfort, fullness, epigastric pain, etc.

Contraindications

The use of domperidone is contraindicated in cases of “Prolactin secreting pituitary tumor”, along with the prescription of triazole anti-fungal medications (for example, fluconazole, itraconazole, ketoconazole, etc.), QT-prolonging medicines, amiodarone, potent CYP3A4 inhibitors, macrolide antibiotics (for example, clarithromycin, erythromycin, etc.). Moreover, it is also contraindicated in the extensive disorders such as cardiac disease, moderate liver disease or hepatic impairment, mechanical bowel disorders, for example bowel perforation, gastrointestinal haemorrhage, bowel obstruction, etc.

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